This study evaluates a theoretical model exploring the relationships among four key constructs: social responsibility, reputation, loyalty, and operational performance. Using a sample of 370 patients at an Phuoc General Hospital in Phan Thiet City, Binh Thuan Province, Vietnam. The data was processed and analyzed using Partial Least Squares-Structural Equation Modeling (PLS-SEM) with Bootstrap analysis to test the reliability of the model. The findings highlight the mediating roles of reputation and loyalty in linking social responsibility to hospital performance.